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Our group is interested in understanding the molecular control of actin driven processes. How does the actin cytoskeleton control changes in cell shape and cell motility in a living organism? We use Drosophila as a model system that allows combining genetics, live-imaging analyses with cell biological and biochemical approaches to identify and characterize regulatory components and signals controlling actin dynamics during development.

 

Axonal targeting of retinal neurons in the larval visual system

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3D-reconstruction of a wild type third instar optic lobe, stained for WRC component Sra-1 (red) and photoreceptor axons (green).