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Our group is interested in understanding the molecular control of actin driven processes. How does the actin cytoskeleton control changes in cell shape and cell motility in a living organism? We use Drosophila as a model system that allows combining genetics, live-imaging analyses with cell biological and biochemical approaches to identify and characterize regulatory components and signals controlling actin dynamics during development.
Directed cell migration of macrophages upon wound-induced immune response
Spinning disc microscopy video. Directed migration of macrophages expressing Lifeact-EGFP imaged from a wing of a wild type pupa (20 APF) upon laser-induced ablation of a single cell (position is marked by a white circle).