Welcome to our pages
Our group is interested in understanding the molecular control of actin driven processes. How does the actin cytoskeleton control changes in cell shape and cell motility in a living organism? We use Drosophila as a model system that allows combining genetics, live-imaging analyses with cell biological and biochemical approaches to identify and characterize regulatory components and signals controlling actin dynamics during development.
Planar-polarized cell migration of follicle epithelial cells during oogenesis
4D live imaging of an ovariole expressing Lifeact-GFP in follicle epithelial cells with 70 µm maximal projection. In stage 6 and 7 follicle epithelia cells are rotating perpendicular to the A-P axis as previously reported by Haigo and Bilder (Science, 2011). Note also stage 9 follicles do not rotate but border cells started to migrate. Movie length is about 4 hours with 2-min time points.