Towards a better understanding of actin dynamics in vivo – a high resolution view of the fly actin cytoskeleton

Eukaryotic cells have evolved a multitude of actin binding proteins that maintain the pool of actin monomers, promote actin nucleation, restrict the length of actin filaments and cross-link filaments into networks or bundles. Thus, these accessory proteins also define the mechanical and dynamic properties of actin filaments and differentially control the organization of actin filaments into higher-order structures adapted to fulfill distinct cellular functions. How are these functions controlled? A better mechanistic understanding of their subcellular and developmental functions at distinct or overlapping membrane compartments requires new microscopy techniques which allow to visualize and compare protein localization as well as actin structures at high spatial and temporal resolution in different genetic backgrounds.

 

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